Home Radiation PET/CT results predict post-treatment radiation-induced hypothyroidism

PET/CT results predict post-treatment radiation-induced hypothyroidism


In patients undergoing radiation treatment for head and neck cancers, thyroid functioning volume derived from 18F-FDG PET/CT is a good indicator of who will develop radiation-induced hypothyroidism. [1].

Radiation-induced hypothyroidism (RIHT) is an adverse effect that usually manifests years after treatment has ended. Although common, it is still underdiagnosed, in part because of its minute symptoms, but this is more likely due to a lack of follow-up consensus in patients treated with RT for head and neck cancers. neck.

This is what led researchers to study the prognostic value of early post-treatment PET/CT examinations with 18F-FDG in predicting the onset of radiation-induced hypothyroidism. For their study, the experts included 53 patients who underwent radiotherapy for nasopharyngeal or oropharyngeal cancer, each of whom also had 18F-FDG PET/CT within 180 days of their final treatment.

RIHT occurred in 42% of patients. In patients who developed RIHT, thyroid functioning volume was noted to be significantly lower. The thyroid volume before treatment and the mean dose of radiotherapy to the thyroid also differed between the groups. The combination of 18F-FDG uptake and a thyroid functional volume threshold of 14.01 gave an AUC of 0.89, along with high sensitivity, specificity, and positive predictive value in predicting which patients would develop RIHT.